DNA Methylation Molecular Biology and Biological Significance

نویسندگان

  • J. P. Jost
  • H. P. Saluz
چکیده

Major techniques to study DNA methylation 11 W. Zacharias Methylation of cytosine influences the DNA structure 27 M. Noy er-Weidner and T. A. Trautner Methylation of DNA in prokaryotes 39 H. Leonhardt and T. H. Bestor Structure, function and regulation of mammalian DNA methyl-transferase 109 Effect of DNA methylation on the binding of vertebrate and plant proteins to DNA 145 F. Antequera and A. Bird CpG Islands 169 The role of DNA methylation in the regulation of plant expression 218 W. Doerfler Pattern of de novo methylation and promoter inhibition: studies on the adenovirus and the human genome 262 D. P. Bednarik DNA methylation and retrovirus expression 300 Effect of DNA methylation on dynamic properties of the helix and nuclear protein binding in the H-ras promoter 330 A. Razin and H. Cedar DNA methylation and embryogenesis 343 J. Singer-Sam and A. D. Riggs X chromosome inactivation and DNA methylation 358 C. Chu and C. K. J. Shen DNA methylation: Its possible functional role in developmental regulation of human globin gene families 385 M. Graessmann and A. Graessmann DNA methylation, chromatin structure and the regulation of gene expression 404 J. P. Jost and H. P. Saluz Steroid hormone-dependent changes in DNA methylation and its significance for the activation or silencing of specific genes ... 425 The repair of 5-methylcytosine deamination damage 510 A. Yeivin and A. Razin Gene methylation patterns and expression 523 Index 569

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Study of promoter CpG island hypermethylation of cyclindependent kinase inhibitor gene p21waf1/cip1 on some breast carcinoma cell lines

The p21 belongs to the CIP/KIP family of CDK inhibitors involved in cell cycle arrest at specific stages of the cell cycle progression. DNA methylation is the best studied epigenetic mark that have been evidently associated to chromatin condensation, and repression of gene transcription. The CpG island hypermethylation in promoter region of certain genes occurs in cancer cells and affects tumor...

متن کامل

Molecular characterization and DNA methylation profile of Libyodrilus violaceous from oil polluted soil

Studies on earthworms using molecular markers are rare in Africa except a handful from South Africa. Reports on Libyodrilus violaceous,an earthworm found in West Africaare available including their metal tolerance and bioaccumulation capacity but their molecular characterization and ecotoxicology studies are scarce. In this study, triplicate L. violaceous specimens were collec...

متن کامل

A convenient method to generate methylated and un-methylated control DNA in methylation studies

Methylated and un-methylated control DNA is an important part of DNA methylation studies. Although human and mouse DNA methylation control sets are commercially available, in case of methylation studies on other species such as animals, plants, and bacteria, control sets need to be prepared. In this paper a simple method of generating methylated and un-methylated control DNA is described. Whole...

متن کامل

Augmented expression levels of lncRNAs ecCEBPA and UCA1 in gastric cancer tissues and their clinical significance

Objective(s): As the second cause of cancer death, gastric cancer (GC) is one of the eminent dilemmas all over the world, therefore investigating the molecular mechanisms involved in this cancer is pivotal. Unrestricted proliferation is one of the characteristics of cancerous cells, which is due to deficiency in cell regulatory systems. Long non-coding RNAs (lncRNAs) have emerged as critical re...

متن کامل

Analyses of methylation status of CpG islands in promoters of miR-9 genes family in human gastric adenocarcinoma

In the recent years deregulation for microRNAs expression pattern have emerged as a possible molecular factor for carcinogenesis. It has been reported that the expression of miR-9 was down-regulated in human gastric adenocarcinoma. To figure out the molecular mechanism of this down regulation, the methylation status in promoters of miR-9 family loci were compared in the human gastric adenocarci...

متن کامل

A preliminary study of the association between the ABCA1 gene promoter DNA methylation and coronary artery disease risk

Coronary artery disease (CAD) is a common health problem in Iranian population. ATP binding cassette transporter A1 (ABCA1) plays central role in the efflux of the cholesterol from peripheral tissues back to liver. Inactivation of ABCA1 by epigenetic change such as DNA methylation may contribute to the development of CAD. The present study investigated the association between promoter DNA methy...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010